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CD10 GPR77 Cancer Associated Fibroblasts Promote Cancer
CD10 GPR77 CAFs promote tumor formation and chemoresistance by providing a survival niche for cancer stem cells CSCs Mechanistically CD10 GPR77 CAFs are driven by persistent NF κB activation via p65 phosphorylation and acetylation which is maintained by complement signaling via GPR77 a C5a receptor
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C5aR2 also referred to as C5L2 or GPR77 is abundantly expressed in human tissues such as the bone marrow spleen and lungs 25 It displays predominant intracellular expression in most myeloid cells and selected T cell subsets such as neutrophils monocytes monocyte derived macrophages and NK cells 29